Fig. 2

Results of dual luciferase assays where HEK293 cells were co-transfected with plasmid constructs carrying either the rs7079 C or the rs7079 A allele of the angiotensinogen gene (AGT), as well as either non-targeting miRNA (white bars; negative control), mRNA mimic miR-31-5p (black bars), or mRNA mimic miR-584-5p (gray bar). a: without lead. b: treated with 5 μM lead acetate. Luciferase activity is shown relative to the negative control. Bars represent means ± standard deviations of three independent transfection experiments. *, P = 0.01; ***, P < 0.001